New position (August 2017):

LabEx Milieu Interieur Senior Data Scientist

Open position at Institut Pasteur (Paris, France)



Read our latest publication in Cell Reports and discover a new approach for deciphering complex immune responses




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Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

S. Kilens, D. Meistermann, D. Moreno, C. Chariau, A. Gaignerie, A. Reignier, Y. Lelièvre, M. Casanova, et al. , Laurent David & The Milieu Intérieur Consortium

Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental biology and regenerative medicine, notably because they circumvent the use of cells of embryonic origin and offer the potential to generate patient-specific pluripotent stem cells. However, conventional...

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.

Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium

The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and...


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