Lluis Quintana-Murci joins the COVID Human Genetic effort


Why are some young, healthy individuals getting severe COVID19?

Why are some individuals resistant to the SARS-CoV2 infection despite repeated exposure?

Lluis Quintana-Murci (co-coordinator - Milieu Intérieur) has joined the COVID Human Genetic Effort which aims to answer these questions using functional genomics analyses.

Directed by Dr. Jean-Laurent Casanova and Helen Su, the COVID Human Genetic Effort is a consortium of world-leading experts that aims to discover

(i) Monogenic inborn errors of immunity (IEI), rare or common, underlying severe forms of COVID-19 in previously healthy individuals

(ii) Monogenic variations, rare or common, making certain individuals resistant to the infection by the SARS-CoV2, despite repeated exposure.

Dr. Quintana-Murci will contribute by utilising his expertise in population genetics towards understanding the sources of the natural variability of immune responses to SARS-CoV-2. He aims to integrate the genetics of the individuals, their ethnic ancestry, as well as their sex, age and BMI - factors that can potentially affect the observed variability in clinical outcome following SARS-CoV-2 infection - to find answers to the 2 key questions. 

This consortium includes investigators representing over 20 countries across 5 continents and more than 30 collaborating institutes. So far more than 300 patients under age 50 who had no existing medical condition but had been admitted to the ICU for COVID-19 have enrolled in this study. 

We will keep you updated on the progress of this study on the Milieu Intérieur website.

Read more about Professor Lluis Quintana-Murci - Chair of Human Genomics and Evolution at Collège de France

Read more about the Human Evolutionary Genetics lab at the Pasteur Institute

Read Press reports on the COVID Human Genetic Effort

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Evolutionary and population (epi)genetics of immunity to infection

Luis B. Barreiro and Lluis Quintana-Murci

In this review, the authors discuss how the integration of population genetics with functional genomics in diverse human populations can inform about the changes in immune functions related to major lifestyle transitions (e.g., from hunting and gathering to farming), the action of natural...


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