News

New position (August 2017):

LabEx Milieu Interieur Senior Data Scientist

Open position at Institut Pasteur (Paris, France)

 

http://www.milieuinterieur.fr/en/about-us/recruitment

 

 

Read our latest publication in Cell Reports and discover a new approach for deciphering complex immune responses

 

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Publications

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.

Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium
Abstract

The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and...

Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity.

07.13.2017
Bisiaux A, Boussier J, Duffy D, Quintana-Murci L, Fontes M, Albert ML; Milieu Intérieur Consortium.

Bacillus Calmette–Guérin (BCG) is used as a vaccine and diagnostic test for tuberculosis, as well as immunotherapy in the treatment of bladder cancer. While clinically useful, the response to mycobacterial stimulation is complex and the induced protein signature remains poorly defined. We...

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