News

Take part in the Curie-O-SA project to improve understanding of immune responses to SARS-CoV-2

The Institut Pasteur is joining forces with the Institut Curie for the Curie-O-SA project aimed at investigating the immune response to the SARS-CoV-2 virus in hospital and non-hospital staff, whether infected or not by the SARS-CoV-2 virus since January 2020.

The Institut Pasteur will analyze blood samples and nasopharyngeal swabs to investigate the seroprevalence and persistence of the systemic humoral response (Thierry Rose) and to search for antibodies against SARS-CoV-2 in the nasal mucosa (James Di Santo and Darragh Duffy).

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Lluis Quintana-Murci joins the COVID Human Genetic effort

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Why are some young, healthy individuals getting severe COVID19?

Why are some individuals resistant to the SARS-CoV2 infection despite repeated exposure?

Lluis Quintana-Murci (co-coordinator - Milieu Intérieur) has joined the COVID Human Genetic Effort which aims to answer these questions using functional genomics analyses.

Directed by Dr. Jean-Laurent Casanova and Helen Su, the COVID Human Genetic Effort is a consortium of world-leading experts that aims to discover

(i) Monogenic inborn errors of immunity (IEI), rare or common, underlying severe forms of COVID-19 in previously healthy individuals

(ii) Monogenic variations, rare or common, making certain individuals resistant to the infection by the SARS-CoV2, despite repeated exposure.

Dr. Quintana-Murci will contribute by utilising his expertise in population genetics towards understanding the sources of the natural variability of immune responses to SARS-CoV-2. He aims to integrate the genetics of the individuals, their ethnic ancestry, as well as their sex, age and BMI - factors that can potentially affect the observed variability in clinical outcome following SARS-CoV-2 infection - to find answers to the 2 key questions. 

This consortium includes investigators representing over 20 countries across 5 continents and more than 30 collaborating institutes. So far more than 300 patients under age 50 who had no existing medical condition but had been admitted to the ICU for COVID-19 have enrolled in this study. 

We will keep you updated on the progress of this study on the Milieu Intérieur website.

Read more about Professor Lluis Quintana-Murci - Chair of Human Genomics and Evolution at Collège de France

Read more about the Human Evolutionary Genetics lab at the Pasteur Institute

Read Press reports on the COVID Human Genetic Effort

 

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Publications

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

06.06.2020
Rodrigues KB, Dufort MJ, Llibre A, Speake C, Jubayer Rahman M, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbel KV

Self-antigen-specific T cell responses drive type 1 diabetes pathogenesis, but alterations in innate immune responses are also critical and not as well understood. Innate immunity in human type 1 diabetes has primarily been assessed via gene-expression analysis of unstimulated peripheral blood...

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes

Rausell A, Luo Y, Lopez M, Seeleuthner Y, Rapaport F, Favier A, Stenson PD, Cooper DN, Patin E, Casanova JL, Quintana-Murci L, Abel L

Human genes homozygous for apparent loss of function (LoF) variants are increasingly reported in a sizeable proportion of individuals without overt clinical phenotypes. Here, we found 166 genes with 179 predicted LoF variants for which the frequency of homozygous individuals exceeds 1% in at...

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