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Le projet Milieu Intérieur: comprendre la diversité humaine…

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Publications

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.

27.07.2018
Petar Scepanovic, Cécile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, E. Patin, C. Wandall Thorball, N. Chaturvedi, B. Charbit, L. Abel, Lluis Quintana-Murci, Darragh Duffy, Matthew L. Albert, Jacques Fellay, The Milieu Intérieur Consortium
BACKGROUND:

Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii)...

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly et al. and The Milieu Intérieur Consortium

The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined...

anr.jpgInvestissements d'avenirInstitut Pasteur InsermCNRShotscreen_1.jpgMYRIAD RBMInstitut Curie Etude Nutrinet Santé  PARCC Université Paris 13 Nord Université Paris Diderot Paris 7lund_univ.gif   epfl.png