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Le projet Milieu Intérieur: comprendre la diversité humaine…

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Publications

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

05.09.2018
Clave E, Araujo IL, Alanio C, Patin E, Bergstedt J, Urrutia A, Lopez-Lastra S, Li Y, Charbit B, MacPherson CR, Hasan M, Melo-Lima BL, Douay C, Saut N, Germain M, Trégouët DA et al., Toubert A and The Milieu Interieur Consortium
Abstract

The thymus is the primary lymphoid organ where naïve T cells are generated; however, with the exception of age, the parameters that govern its function in healthy humans remain unknown. We characterized the variability of thymic function among 1000 age- and sex-stratified healthy...

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.

27.07.2018
Petar Scepanovic, Cécile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, E. Patin, C. Wandall Thorball, N. Chaturvedi, B. Charbit, L. Abel, Lluis Quintana-Murci, Darragh Duffy, Matthew L. Albert, Jacques Fellay, The Milieu Intérieur Consortium
BACKGROUND:

Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii)...

anr.jpgInvestissements d'avenirInstitut Pasteur InsermCNRShotscreen_1.jpgMYRIAD RBMInstitut Curie Etude Nutrinet Santé  PARCC Université Paris 13 Nord Université Paris Diderot Paris 7lund_univ.gif   epfl.png