Genetic data

To discover genetic factors affecting human immune responses, we obtained genotypic data for a predefined selection of 730,000 genomic positions that vary within the Milieu Intérieur cohort.

In 2016, we also assessed epigenetic variation at >850,000 genomic positions in the entire cohort, to evaluate how immune variation relates with DNA methylation.

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Genetic data

The publication that describes the genetic data from Milieu Intérieur is:

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors “

In 2018, we have sequenced the whole genomes of all participants at high depth of coverage (30×). We discovered more than 34 million genetic variants, which are currently analyzed by the MI core team.

Epigenetic data

The publication that describes the epigenetic data from Milieu Intérieur is:

The immune factors driving DNA methylation variation in human blood