Demandes d’accès aux données acceptées
Les chercheuses et chercheurs peuvent demander l’accès aux données et/ou aux échantillons biologiques du projet Milieu Intérieur en remplissant le formulaire de demande d’accès aux données
Le Comité d’accès aux données de Milieu Intérieur examine les formulaires de demande d’accès chaque mois et accorde l’accès à tout projet de recherche dont les objectifs sont compatibles avec le consentement éclairé signé par les participants à l’étude. En particulier, la recherche sur les données de Milieu Intérieur est limitée à l’étude des déterminants génétiques et environnementaux de la variation de la réponse immunitaire humaine.
Conditions : Le.La requérant.e devra se conformer à la réglementation en vigueur concernant l’utilisation des données. En aucun cas ces données ne doivent (1) être utilisées pour réidentifier les participants, (2) être transmises à un tiers, (3) être utilisées à des fins diagnostiques, ou (4) être stockées sans chiffrement sur des ordinateurs personnels.
De plus, le Consortium Milieu Intérieur est tenu d’informer en continu les participants à l’étude de tout projet de recherche utilisant leurs données personnelles. Ainsi, le titre du projet et les noms et affiliations des requérant.e.s sont publiés sur cette page une fois le projet approuvé.
Titre – Validity of a new analysis method on published flow cytometry data
Person in charge – Wolfgang Losert
Affiliation – University of Maryland
Titre – Role of HLA ClassII in the humoral response
Person in charge – John Altin
Affiliation – Altin Laboratory, TGEN
Titre – Analysis of cellular signaling pathways and genetic networks in chronic inflammatory diseases patient samples
Person in charge – Lars Rogge
Affiliation – Institut Pasteur
Titre – Characterising the relationship between polygenic risk for autoimmunity and immune responses
Person in charge – Zia Khan (Genentech)
Affiliation – Genentech Inc.
Titre – Understanding the effects of CMV infection
Person in charge – Amir Horowitz
Affiliation – Horowitz Laboratory /Icahn School of Medicine at Mount Sinai
Titre – Immune function in patient undergoing immune modulating interventions
Person in charge – Susanne Dam Poulson
Affiliation – Department of Infectious Disease, University of Copenhagen
Titre – Inter-individual variability of the oxylipin response
Persons in charge – Cecile Gladine and Andre Mazur
Affiliation – UMR 1019 INRA/Université Clermont Auvergne
Titre - Using VirScan to study heterogeneity in pathogen-induced immune responses Persons in charge – Petter BRODIN and Lluis QUINTANA-MURCI
Affiliation – Karolinska Institutet and Institut Pasteur
Titre – Determining the frequency of CD3+CD8+CD16+ T cells in the healthy population Person in charge – Nicolas Degauque
Affiliation – Centre Hospitalier, Universitaire de Nantes
Titre – Epigenomic variation in immune cells associated with aging
Person in charge – Duygu Ucar
Affiliation – Jackson Laboratory for Genomic Medicine
Titre – Causes of natural variation in the immune system – a mendelian Randomisation Persons in charge – George Davey-Smith and Ruth Mitchell
Affiliation – Medical Research Council Integrative Epidemiology Unit (MRC IEU), University of Bristol
Titre – Variability in induced immune responses to TLR stimulation
Person in charge – Allyson Byrd and Matthew ALBERT
Affiliation – Genentech Inc.
Titre - Characterisation of the innate immune system of Exposed Seronegative women from the Irish anti-D cohort to understand mechanisms of natural resistance to viral infection.
Person in charge – Cliona O'FARELLY
Affiliation – Trinity College Dublin
Titre – Late-Spike haplotype dosage association with immune cell type abundances or marker abundances
Person in charge – Soumya Raychaudhuri and Maria Gutierrez-Arcelus
Affiliation – Broad Insitute of Harvard and MIT.
Titre – Comparison of the Polygenic score between individuals with Bipolardisorder and the healthy population
Person in charge – Stephane Jamain
Affiliation – INSERM U955
Titre – Comparison of Milieu Intérieur immune response data with samples from patients with primary immunodeficiencies
Person in charge – Petter Brodin
Affiliation – Karolinska Institutet
Titre – Identification of the dietary patterns to explain gut microbiome configurations Person in charge – Julien Tap
Affiliation – Danone Research
Titre - Evaluating the level of Candida colonization
Person in charge - Christophe D’Enfert and Marie-Elisabeth Bougnoux
Affiliation – Institut Pasteur
Titre – Soluble immune inhibitory factors as drivers of immune (dys)function in health and disease
Person in charge – Sisse Rye Ostrowski
Affiliation – Department of Clinical Immunology, University of Copenhagen
Titre – Defining how the microbiome at a functional level influences a healthy immune response
Person in charge – Darragh Duffy, Deepti Nagarkar, Allyson Byrd, Magnus Fontes.Affiliation – Institut Pasteur, Genentech, Institut Roche
Lien vers la fiche d'information
Titre – Effects of detailed immune cell phenotypes on common immune-mediated diseases, using an Mendelian randomisation (MR) approach.
Personin charge – Petar Scepanovic and Elias Allara
Affiliation – University of Cambridge
Titre – Prospective study of Gut microbiome-Immunome relations in the context of the man-microbes symbiosis as a key feature in health and disease.
Person in charge – Sébastien Fromentin
Affiliation – MetaGenoPolis lab INRA
Titre – Investigating immune profile datasets from the MIC to better understand environmental and genetic sources of immune variation.
Person in charge – Joseph C. Devlin
Affiliation – New York University
Titre – Role of inborn errors of immunity in response to SAR-CoV2 infection
Person in charge – Jean-Laurent Casanova
Affiliation – INSERM
Titre – Metabolomic analysis og the gut microbiota to better understand how it impacts a healthy human response (continuity of the previous Genentech collaboration, see above)
Person in charge – Allyson Byrd
Affiliation – Genentech
Titre – Impact of CMV status on lymphocyte subpopulations in cancer patients and healthy donors.
Person in charge – Ana Lalanne
Affiliation – Institut Curie
Titre – Study of genomic structural variation in the MIC, and its impact on immune phenotype variability and its heritability.
Person in charge – Rayan Chikhi and Riccardo Vicedomini
Affiliation – Institut Pasteur
Titre – Genome-Wide Association Study (GWAS) to identify genetic variants associated with susceptibility and severity to COVID19 in the French population
Person in charge – Hanna Julienne, Léo Hanches and Hugues Aschard
Affiliation – Institut Pasteur
Titre – Identify the transcriptomics signature of latent CMV infection
Person in charge – Atul Butte, Hu Zicheng
Affiliation – University of California San Francisco
Titre – Understanding variable immunity to respiratory infections with an aim to improve vaccination strategies
Person in charge – Darragh Duffy, Jim Di Santo, & Daniel Larocque
Affiliation – Institut Pasteur, Sanofi Pasteur
Titre – Identifying representative individuals as faecal donor candidates to create an adult rat model transplanted with human fecal samples by using microbiota information of the MIC.
Person in charge – Mathieu Almeida, Nicolas Pons
Affiliation – INRAE
Titre – Integrating genetic and microbiome risk profiles for disease prediction using multivariate analysis
Person in charge – Petar Scepanovic
Affiliation – Roche Basel, Switzerland
Titre – Establishing a baseline gut microbiota index of healthy volunteers.
Person in charge – Rafi Ahmad
Affiliation – Inland Norway University
Titre – MICMAT
Person in charge – Christophe Boetto, Hugues Aschard
Affiliation – Institut Pasteur
Titre – Exploring Pathogenic Mechanisms of Chronic Inflammatory Diseases: unresolved issues in IL-23/IL-17 biology
Person in charge – Ikram Mezgiche, Elisabetta Bianchi, Lars Rogge
Affiliation – Institut Pasteur
Titre – Pilot study for the evaluation of innate responses from phagocytes differentiated from iPSCs generated by MIC.
Person in charge – Pierre Guermonprez
Affiliation – Université de Paris
Titre – Influence of sex hormones on anti-bacterial immunity
Person in charge – Molly Ingersoll
Affiliation – Institut Pasteur/Cochin Institut
Titre – Human genetic susceptibility to invasive listeriosis
Person in charge – Marc Lecuit
Affiliation – Institut Pasteur
Titre – Assessing the influence of confounding factors and sequencing technology on
microbiome composition
Person in charge – Jacob Wirbel, Georg Zeller
Affiliation – EMBL-Heidelberg
Titre – Genetic determinants of COVID-19 disease
Person in charge – Hugues ASCHARD - COVID GWAS
Affiliation – Institut Pasteur
Titre – An ethnically diverse genomic reference resource for the human heavy and light chain immunoglobulin loci
Person in charge – Melissa Smith, Ronald Gregg
Affiliation – University of Louisville School of Medicine
Titre – Immunological landscape representation by unsupervised machine learning for mapping of immune dysfunction
Person in charge – Adrian Zucco, Cameron MacPherson
Affiliation – Rigshospitalet, Copenhagen
Titre – “Toxic” microbiome and progression of chronic kidney disease. A prospective study
Person in charge – Florence Thirion
Affiliation – INRAE, MetaGenoPolis
Titre – The role of the microbiota -triggered antigen stimulation in development and progression of chronic lymphocytic leukemia
Person in charge – Michal Kielbs, Krzysztof Giannopoulos
Affiliation – Medical University of Lublin Chodzki
Title – Role of the microbiota in the defense against multridrug resistant Enterobacteriaceae
Person in charge – Carles Ubeda
Affiliation – Microbiota, infection, and inflammation – FISABIO
Title – Understanding functional relevance of inter-individual variations in microbiota composition
Person in charge – Benoit Chassaing
Affiliation – INSERM U1016, Université de Paris, Institut Cochin
Title – Identification of genetic variants associated with thrombotic thrombocytopenic purpura
Person in charge – Thierry Hieu, Anavaj Sakuntabhai
Affiliation – Institut Pasteur
Title – Development of novel genotype-phenotype association framework for mechanistic microbiome study
Person in charge – Menghan Liu
Affiliation – Columbia University
Title – A low-dimensional consensus map relating variability in autoimmune disease to variability in healthy individuals
Person in charge – Behnam Yousefi, Benno Schwikowski
Affiliation – Institut Pasteur
Title – Understanding at a functional level what determines observed variance in immune responses to TLR stimulation in a healthy human population.
Person in charge – Magnus Fontes
Affiliation – Institut Roche/Genentech
Title – Serological assessment of antibody responses to routine vaccines and respiratory virus infection.
Person in charge – Michael White
Affiliation – Institut Pasteur
Title – Understanding the role of microbial and lifestyle factors as regulators of haematopoiesis in healthy individuals
Person in charge – Jason Cosgrove
Affiliation – Institut Curie
Title – Large-scale exploration of the microbiome/immunome dialogue in autoimmune diseases
Person in charge – Oscar Gitton-Quent
Affiliation – MetaGenoPolis – INRAE
Title – A cis-regulatory element drives the expression of ERAP2 through autoimmune disease risk SNPs
Person in charge – Jonas Kuiper
Affiliation – Kuiper Lab, University Medical Center Utrecht
Title – Using Machine Learning to Discern the Cellular Mechanism(s) Underpinning the Influence of KIR-HLA genotype on T-cell Dynamics
Person in charge – Becca Asquith
Affiliation – Department of Infectious Disease, Imperial College London
Title – iTARGET
Person in charge – Victoria Meslier and Mathieu Almeida
Affiliation – MetaGenoPolis, INRAE
Title – Functional Interactions and Global Diversity in Gut Microbiomes: Advancing Microbial Community Type Identification with Deep Learning Approaches
Person in charge – Vanessa Dumeaux
Affiliation – Dumeaux Laboratory, Western University
Title – Gene editing of the SNP rs2204985 associated with thymopoiesis level in healthy humans
Person in charge – Antoine TOUBERT
Affiliation – INSERM U1160, Institut de Recherche Saint-Louis, Université de Paris.
Title – Development of an explainable AI-based platform predicting biological and clinical features based on DNA methylation
Person in charge – Vincent Bouget
Affiliation – Scienta Lab
Lien vers la fiche d'information
Title – Parameters governing the human thymic function during aging
Person in charge – Antoine TOUBERT
Affiliation – Institut de Recherche Saint-Louis, Université de Paris
Title – Vieillissement, Infections et Épigénétique – Investigating how Viral Infections Shape Epigenetic Ageing and Health
Person in charge – Matt McElheron and Nollaig Bourke
Affiliation – Trinity College Dublin, Ireland
Title - Characterisation of the crosstalk between Archaea and Negativicutes with the intestinal mucosa in the context of health and inflammation
Person in charge – Camille Martin-Gallausiaux and Simonetta Gribaldo
Affiliation – Institut Pasteur
Title - Development of network analysis tools for deciphering the interactions and organization of microbial guilds
Person in charge - Magali Berland
Affiliation - MetaGenoPolis, INRAE
Title - Immunity, Inflammation, and Coagulation in COVID-19: a cohort study of Fiocruz workers
Person in charge - Itauá Leston Araujo and Adriana Bonomo
Affiliation - Laboratory on Thymus Research - Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro-Brazil
Title - MICMAT --> request to expand dataset. raw data for the Shotgun data for fecal microbiota (see above MICMAT 1st request for collaboration).
Person in charge - Raphael MALAK and Hugues Aschard
Affiliation - Institut Pasteur
Title - Cytokine autoantibody prevalence and functional implications
Person in charge - Nils Landegren
Affiliation - Uppsala University
Lien vers la fiche d'information
Title - Impact of rs2204985 on peripheral blood mononuclear cells composition
Person in charge - Vivien Beziat
Affiliation - INSERM - Institut Imagine
Title - Fine tuning of the Genetic association with human thymic function
Person in charge - Emmanuel Clave and Antoine Toubert
Affiliation - Institut de Recherche Saint-Louis
Title - Age associated immune cell signatures in a diverse healthy American
Person in charge - Hanane Touil and Philip De Jager
Affiliation - Columbia University – De Jager Lab
Title - Rhu immunolife
Person in charge - Giacomo Vitali and Mathieu Almeida
Affiliation - MetaGenoPolis - INRAe
Title - Role of polymoprhisms in IL23R in TB
Person in charge - Boisson-Dupuis Stephanie and Jean-Laurent Casanova
Affiliation - Imagine Institute INSERM 1163
Title - Cellular and molecular correlates of hematopoietic aging and cancer risk
Person in charge - Matthew Park and Nader Yatim
Affiliation - Icahn School of Medicine at Mount Sinai
Title - Polygenic risk score development for Ebstein barr virus (EBV) antibody production.
Person in charge - Bahram Namjou
Affiliation - Center for Autoimmune Genomics and Etiology (CAGE) -Cincinnati Children Hospital (CCHMC), Ohio
Title - To implement healthy ranges for immune phenotypes as determined across age, sex, and CMV status in the MI cohort into our daily practice at the Laboratoire d’Immunologie Clinique of the Institut Curie
Person in charge - Cécile Alanio
Affiliation - Immunologie Clinique - Institution Institut Curie
Title - Maternal Immunity Control of Early Life (MAMM)
Person in charge - Clarisse Ganier
Affiliation – Meta-Organism Lab - Institut Pasteur
Title - Healthy Human Global Project – Hong Kong - Workshop
Person in charge - Darragh DUFFY
Affiliation - Institut Pasteur & IP Hong Kong, & C2i
Title - Development of an explainable AI-based platform predicting biological and clinical features based on DNA methylation
Person in charge - Vincent Bouget
Affiliation - Scienta Lab
Title - Le French Gut
Person in charge - Amine Ghozlane
Affiliation - Institut Pasteur - Le French Gut
Title - Characterization of large-scale ‘gut microbiota-diet-health’ relationships in human, using combined ap-proaches of digital microbial ecology, metabolic modeling and artificial intelligence
Person in charge - Mathilde Sola
Affiliation - MetaGenoPolis – INRAE
Title - Identification of MHC Class II peptide generation constraints affecting T cell-B cell cooperation
Person in charge - Jennifer Mamrosh
Affiliation - Los Alamos National - Laboratory, T-6 group
Title - Identification of Genetic variants regulating gEne hubs in the cOntrol of specific and generic modules across contect-dependent activation of Immune Cells in healthy subjects: Understanding the genetic architecture Of Disease sEverity in IBD (GEOCODE Project)
Person in charge - Claire Liefferinckx
Affiliation - Lab. of experimental gastro-enterology Université Libre de Bruxelles
Title - Genetic associations of IL-1alpha autoantibodies
Person in charge – Kai Kisand
Affiliation - Institute of Biomedicine and Translational Medicine - University of Tartu
Title - Multi-omic study in patients with SITRAME syndrome
Person in charge - Institut Pasteur and CNRS
Affiliation - Darragh Duffy and Mathieu Rodero
Title - Longitudinal characterization of type-I interferon -specific B cells
Person in charge - Matthieu MAHEVAS
Affiliation - Auto-immune and Immne B cells (INEM) lab - Institut Necker Enfant-Malades (Inserm U11-51, Université Paris Cité)
Title - V1 microbiome with hormone levels (ongoing collaboration)
Person in charge - Allyson Byrd and Darragh Duffy
Affiliation - Benaroya Research Institute and Institut Pasteur
Title - Understanding the effects of environmental chemicals on human immune responses through social factor interactions
Person in charge - Nadine Hamieh et Michelle Kelly-Irving
Affiliation - CERPOP – Centre d'Epidemiologie et de Recherche en Santé des Populations - INSERM
Title - Analysis of the worldwide distribution of the gut commensal SFB using bioinformatic analysis
Person in charge - Pamela Schnupf
Affiliation - Host-Microbiota Interaction – Institute Necker Enfants Malades (INEM)
Title – EU Twinning grant SysAge – Tartu Workshop
Person in charge – Darragh Duffy
Affiliation - Translational Immunology Unit - Institut Pasteur & University of Tartu
Title - Exploring Sex Hormone-Mediated Alterations in Immunometabolites among Transgender and Cisgender Individuals
Person in charge - Ahmet Yalcinkaya and Nils Landegren
Affiliation - Landegren Autoimmunity Lab (Uppsala University)
Title - Healthys CD3s
Person in charge - Cécile ALANIO
Affiliation - Hôpital Foch – Laboratoire de Biologie Clinique